Prof. Smadar Cohen
Born: 1958, Israel
Academic Qualifications:
    Ph.D. 1988, Tel-Aviv University
    Full Professor 2004.
Academic Positions:
Department of Biotechnology Engineering - Professor

Research Interests:
Biomaterials. Bioreactors. Cell and tissue engineering. Regenerative Medicine. Stem Cells. Nano/Microparticles for controlled delivery of DNA, peptides and proteins.
Research Projects:
Instructive biomaterials inducing tissue regeneration and engineering.
Designer scaffolds/bioreactors for controlled differentiation of stem cells.
Cardiac tissue engineering.
Liver tissue engineering.
Vascularization of engineered tissues.
Targted delivery of nanoparticles to melanoma metastases
Abstracts of Current Research:
  • Effect of Injectable Alginate Implant on Cardiac Remodeling
    and Function After Recent and Old Infarcts in Rat
    : Adverse cardiac remodeling and progression of heart failure after myocardial infarction are associated with excessive and continuous damage to the extra-cellular matrix. We showed that injection of in situ–forming alginate hydrogel into recent and old infarcts provide a temporary scaffold and attenuate adverse cardiac remodeling and dysfunction.(Circulation. 2008;117:1388-1396.)
  • Induced differentiation and maturation of newborn
    liver cells into functional hepatic tissue in macroporous alginate scaffolds
    : The present work explores cell cultivation in macroporous alginate scaffolds as a means to reproduce hepatocyte terminal differentiation in vitro.
    (FASEB J.2008; 22: 1440–1449)
  • The effect of sulfation of alginate hydrogels on the specific binding
    and controlled release of heparin-binding proteins
    : To mimic the high affinity of heparin-binding proteins to heparin/heparan sulfate, the uronic acids in non-sulfated alginate were sulfated, and hydrogels of mixed alginate/ alginate-sulfate were fabricated. Mixed hydrogels of alginate/alginate-sulfate sustained the release of basic FGF, with the release rate being dependent on the percentage of bFGF bound to the hydrogels. In vivo, the delivery of bFGF bound to alginate/alginate-sulfate
    scaffolds induced the formation of twice the number of blood vessels compared to when bFGF was delivered adsorbed to the matrix and 51% of the vessels were matured, as judged by pericyte coverage of the vessels. Our results thus describe the engineering of alginate hydrogels for the spatially presentation and controlled delivery of heparin-binding proteins.(Biomaterials 2008;29:3260–3268)
Publications:
  • Inbar Freeman, Alon Kedem, Smadar Cohen. The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins Biomaterials 29: 3260–3268 (2008)
  • Landa N, Miller L, Feinberg MS, Holbova R, Shachar M, Freeman I, Cohen S*, Leor J*.. Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarct. Circulation 117: 1388-1396 (2008)
  • Dvir-Ginzberg M, Elkayam T and Cohen S. . Induced differentiation and maturation of newborn liver cells into functional hepatic tissue in macroporous alginate scaffolds. FASEB J. 22: 1440-1449 (2008)
  • Levy O, Dvir T, Shachar M, Granot Y, Cohen S. . Signal transducer and activator of transcription 3—A key molecular switch for human mesenchymal stem cell proliferation The InternationalJournal of Biochemistry & Cell Biology 40: 2606–2618 (2008)
  • Lavi G, Voronov E, Dinarello CA, Apte RN, Cohen S . Sustained delivery of IL-1Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases. J Control Rel 123: 123-130 (2007)
  • Leor J, Gerecht-Nir S, Cohen S, Miller L, Zarin P, Holbova R, Ziskind A, Shachar M, Guetta E, Itskovitz-Eldor J. . Human embryonic stem cell transplantation to repair the infarcted myocardium. Heart 93: 1278–1284 (2007)
  • Dvir T, Levy O, Shachar M, Granot Y, and Cohen S. . Pulsatile interstitial fluid flow activates ERK1/2 signaling cascade in neonatal myocyte 3-D culture, leading to adult cardiac muscle regeneration. Tissue Engineering 13: 2185-2193 (2007)
Keywords:Biotechnology, Cardiac Regeneration, Tissue Engineering, Regenerative Medicine, Biomaterials, Drug Delivery Systems, Stem Cells.
Phones:
  1. Phone: 972-8-6461798
  2. Fax: 972-8-6472915
Email:scohen@bgu.ac.il