Abstracts of Current Research:- Blood pressure and cognitive functioning among independent elderly
Paran, E., Anson, O. and Reuveni, H. : Abstract
Background
The morbidity and mortality benefits of blood pressure (BP) control for the elderly is well documented. The cognitive consequences of hypertension control in this population, however, are still under debate. We aim to study the association between BP and cognitive performance in the elderly. Specifically, we explore 1) the possibility that BP is differentially associated with various cognitive domains; and 2) the utility of analyzing both BP and cognitive scores as continuous variables to unravel possible nonlinear associations.
Methods
Four hundred ninety-five community living 70 to 85 year olds completed eight cognitive tests that measured memory, concentration, visual retention, verbal fluency, and the mini-mental state examination (MMSE). The performance of each test was analyzed first by comparing four groups (normotensives, normalized hypertensives, untreated hypertensives, and treated but uncontrolled hypertensives). Then, using BP values as continuous variables, linear, U-curve, and J-curve associations were estimated.
Results
On all cognitive tests, except for verbal fluency, normotensives performed poorest, treated but uncontrolled hypertensives achieved the highest scores. The MMSE scores and the lighter concentration task were linearly related to BP; J-curve association was observed between memory and visual retention; prolonged concentration was related to pulse pressure alone.
Conclusions
Low BP, as observed among the normotensive subjects, was associated with poor cognitive performance. Mild hypertension appeared to enhance cognitive functioning among the subjects of this study. Moreover, we found support for the hypothesis that the association between BP and different dimensions of cognition take on different patterns.
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Publications:- S.Kobal, E.Paran, A.Jamali, S.Mizrahi, R.Siegel, J.Leor. Pheochromocytoma: cyclic attacks of hypertension alternating with hypotension. Nature clinical practice. Cardiovascular medicine 5: 7 (2008)
- A.Cherubini, D.Lowenthal, E.Paran, P.Mecocci, L.Williams, U.Senin. Hypertension and cognitive function in the elderly. American journal of therapeutics 14: 54 (2007)
- T.Wolak, S.Anfanger, A.Wolak, T.Furman, T.Abuara'ar, A.Biton, D.Pilpel, E.Paran. Target organ damage in hypertensive patients of different ethnic groups. International journal of cardiology 116: 24 (2007)
- D.Lowenthal, E.Paran, L.Burgos, L.Williams. General characteristics of treatable, reversible, and untreatable dementias. The American journal of geriatric cardiology 16: 42 (2007)
- E.Paran, O.Anson. Blood pressure treatment and cognition in the elderly. The American journal of geriatric cardiology 16: 7 (2007)
- Y.Engelhard, B.Gazer, E.Paran. Natural antioxidants from tomato extract reduce blood pressure in patients with grade-1 hypertension: a double-blind, placebo-controlled pilot study. American heart journal 151: 100 (2006)
- Engelhard, Y.N Gazer B. and Paran, E. 151(1) 100-6
. Natural antioxidants from tomato extract reduce blood pressure in grade 1 hypertensive patients: A double blind placebo controlled study. Am.Heart J/ 151: 100-06 (2006)
- I.Hazan-Halevy, T.Levy, T.Wolak, I.Lubarsky, R.Levy, E.Paran. Stimulation of NADPH oxidase by angiotensin II in human neutrophils is mediated by ERK, p38 MAP-kinase and cytosolic phospholipase A2. Journal of hypertension 23: 90 (2005)
- Hazan-Halevy I, Levy T, Wolak T, Lubarsky I, Levy R, Paran E.. Stimulation of NADPH oxidase by angiotensin II in human neutrophils is mediated by ERK, p38 MAP-kinase and cytosolic phospholipase A2.
J. Hypertens. 23: 1183-90 (2005)
- O.Anson, E.Paran. Hypertension and cognitive functioning among the elderly: an overview. American journal of therapeutics 12: 65 (2005)
- Anson, O. and Paran, E. . 2005: 12(4):. Hypertension and cognitive functioning in the elderly: an overview Am. J. Therap 12: 359-65 (2005)
- Paran, E., Anson, O. & Reuveni, H.. Blood pressure and cognitive
functioning among an independent elderly population. Am. J. Hypertens.
16: 818-826 (2003)
- Wolak T., Szendro G., Golcman L. & Paran E.. Malignant hypertension
as a presenting symptom of Takayasu arteritis. Mayo Clin Proc. 78: 231-236 (2003)
- T.Wolak, G.Szendro, L.Golcman, E.Paran. Malignant hypertension as a presenting symptom of Takayasu arteritis. Mayo Clinic proceedings. Mayo Clinic 78: 6 (2003)
- E.Paran, H.Reuveni. Blood pressure and cognitive functioning among independent elderly. American journal of hypertension : journal of the American Society of Hypertension 16: 26 (2003)
- R.Berger, E.Paran. [Stress and hypertension] Harefuah 141: 30, 665 (2002)
- Reuveni, H., Aviram, E.A., Elchayani, A., Lifsihtz, M., Peled, R.,
Galai, N., Sherf, M. & E. Paran.. The prescription pattern of oral
nitrates in coronary artery diseases: appropriateness and cost
considerations. Euro. J. Clin. Pharmacol. 57: 595-597 (2001)
- Palmieri V., Bella JN., DeQuattro V., Roman MJ., Hahn RT., Dahlof
B., Sharpe N., Lau CP., Chen WC., Paran E., De Simone G. & Devereux RB.
. Relations of diastolic left ventricular filling to systolic chamber and
myocardial contractility in hypertensive patients with left ventricular
hypertrophy (the PRESERVE study). Am. J. Cardio. 84(5): 558-562 (2001)
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